Search on: TYPE I SECRETION SYSTEMS 
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Descriptor English:   Type I Secretion Systems 
Descriptor Spanish:   Sistemas de Secreción Tipo I 
Descriptor Portuguese:   Sistemas de Secreção Tipo I 
Synonyms English:   Bacterial Secretion Systems, Type I
Secretion System, T1SS
System, T1SS Secretion
T1SS Secretion System
Type 1 Secretion System
Type 1 Secretion Systems
Type I Secretion System  
Tree Number:   D05.500.890.500.500
Definition English:   Gram-negative bacterial secretion systems which translocate effectors in a single step across the inner and outer membranes. The one-step secretion is carried out by a channel that passes from the CYTOPLASM, through the inner membrane, PERIPLASMIC SPACE, and outer membrane, to the EXTRACELLULAR SPACE. The specificity of type I secretions systems are determined by the specificity of the three subcomponents forming the channel - an ATP transporter (ATP-BINDING CASSETTE TRANSPORTERS); a membrane fusion protein (MEMBRANE FUSION PROTEINS); and an outer membrane protein (BACTERIAL OUTER MEMBRANE PROTEINS.) 
History Note English:   2016 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   55945 
Unique Identifier:   D000069177 

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